The designation would expand the CFTC's mandate to oversee agricultural, energy and financial options markets and pave the way for the agency to regulate other digital assets such as non-fungible tokens, or NFTs.
Separately, the CFTC is considering how carbon trading markets operate, with a view toward their use in hedging and risk management.
Mersinger, one of five commissioners on the independent board that oversees commodity and financial futures markets, was speaking on Tuesday on the sidelines of the Reuters Commodities Trading USA conference in Houston.
Major crypto companies have backed the CFTC and on Tuesday U.S. senators Cynthia Lummis, Republican of Wyoming, and Kirsten Gillibrand, Democrat of New York, filed a bill that would make CFTC the industry's main overseer.
"You're seeing the industry coalesce around the CFTC becoming the primary regulator," said Mersinger.
Lawmakers have not decided which agency would oversee cryptocurrencies but the proposed Lummis-Gillibrand bill offers a starting point for Congressional debate.
The CFTC has begun its own review of a potential role over cryptocurrencies, with staff looking for opportunities in areas such as spot-market crypto trading "where we could have some expanded role making," Mersinger said. She cautioned that the agency historically has not regulated spot markets and its reviews are preliminary.